C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Although this strain is resistant to many tumors, it is a suitable medium for maximal expression of most mutations. C57BL/6J mice are resistant to auditory seizures, have relatively low bone density, and develop age-related hearing loss. They are also prone to diet-induced obesity, type 2 diabetes, and atherosclerosis. Macrophages of this strain are resistant to the effects of the lethal anthrax toxin. This strain can present with alopecia of unknown cause, as well as with hereditary hydrocephalus (1-4% incidence), unperforated vagina after 24-28 days, high rate of malocclusion, high rate of microphthalmia and eye abnormalities, and morphine addiction. And alcohol is determined. .