Swiss/j
Strain Name :RjOrl:SWISS
Type : SPF:Outbred mouse
Colour and related genotype : Albino mouse
Breeding : Good breeder, strong maternal instinct
Swiss outbred mice are an albino stock, produces many litters which are useful in toxicology and pharmacology studies. This strain is moderatory prone to the development of atherosclerosis. Aged mice show a high prevalence of breast and lung tumors. By increasing age, they suffer from polydipsia and polyuria caused by nephrogenic diabetes. This strain is useful for generating transgenic mice because they are high responsive to exogenous hormones. Swiss Outbred mice is versatile outbred mouse, used in all areas of biomedical research (general studies), it is used as donor and/or recipient of embryos.
Main Application And Research Fields
- Behaviour
- General studies
- Immunology
- Metabolism
- Oncology
- Pharmacology
- Physiology, ageing
- Reproduction and embryology
- Teratology
- Toxicology
| Hematological parameters of 10-week old RjOrl:SWISS mice | ||
|---|---|---|
| Parameters | Male | Female |
| Erythrocytes (1012/l) | 9.4 ± 0.5 | 9.0 ± 0.8 |
| Hematocrit (l/l) | 0.55 ± 0.02 | 0.53 ± 0.04 |
| Hemoglobin (g/dl) | 14.4 ± 0.7 | 14.9 ± 0.8 |
| Mean corpuscular volume (fl) | 59 ± 2 | 59 ± 1 |
| Mean corpuscular rate (pg) | 15.3 ± 0.5 | 16.7 ± 0.9 |
| Hemoglobin concentration (g/dl) | 26 ± 1 | 28 ± 1 |
| Blood platelets (109/l) | 1100 ± 213 | 1059 ± 137 |
| Leukocytes (109/l) | 7.8 ± 2.1 | 9.3 ± 3.1 |
| Neutrophils (109/l) | 2.87 ± 0.97 | 1.41 ± 0.58 |
| Lymphocytes (109/l) | 4.44 ± 1.80 | 7.26 ± 2.49 |
| Eosinophils (109/l) | 0.26 ± 0.09 | 0.38 ± 0.16 |
| Monocytes (109/l) | 0.19 ± 0.05 | 0.14 ± 0.06 |
| Basophils (109/l) | 0.05 ± 0.05 | 0.08 ± 0.05 |
| Biochemical blood parameters of 10-week old RjOrl:SWISS mice | ||
|---|---|---|
| Parameters | Male | Female |
| Glucose (g/l) | 2.5 ± 0.4 | 2.1 ± 0.2 |
| Urea (g/l) | 0.5 ± 0.1 | 0.5 ± 0.1 |
| AST (ASAT) (UI/l) | 201 ± 96 | 140 ± 47 |
| ALT (ALAT) (UI/l) | 98 ± 52 | 52 ± 24 |
| Alkaline phosphatase (UI/l) | 62 ± 23 | 70 ± 38 |
| Cholesterolaemia (g/l) | 1.6 ± 0.3 | 1.1 ± 0.2 |
| Triglycerides (g/l) | 1.1 ± 0.3 | 2.2 ± 0.3 |
| Creatinine (mg/l) | 5.1 ± 0.6 | 5.0 ± 0.7 |
| Reproductive data | |
|---|---|
| Bigamous mating according Robertson System | |
| Litter size at birth | 13.5 |
| Weaning % | 91 |
| Productivity index | 3.35 |
| Sterility % | 0 |
| Gestation time | Between 18 and 21 days |
